| A breath test for malignant mesothelioma using an electronic nose. | |
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MedLine Citation:
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PMID: 22183490 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Malignant mesothelioma (MM) is a rare tumour usually caused by asbestos exposure. MM is difficult to diagnose in its early stages and is invariably fatal. Earlier detection of MM could potentially improve survival. Exhaled breath sampling of volatile organic compounds (VOCs) using a carbon polymer array (CPA) electronic nose recognises specific breath profiles characteristic of different diseases. VOC breath profiling can distinguish between patients with lung cancer and controls, but there is only one prior report in MM, and the potential confounding effect of other asbestos-related diseases was not highlighted.A CPA electronic nose will distinguish patients with MM from those with benign asbestos-related diseases (ARDs) and normal subjects with high sensitivity and specificity.Eighty patients (MM n=20, ARDs n=18, controls n=42) participated in a cross-sectional, case control study. Breath samples were analysed using the Cyranose 320, using canonical discriminant analysis and principal component reduction. Repeatability was assessed by evaluating the samples in duplicate.20 MM, 18 ARDs and 42 control subjects could be distinguished by their breath profiles. 10 MM subjects created the training set. Smellprints from 10 new MM patients were distinguished from control subjects with an accuracy of 95%. Patients with MM, ARDs and control subjects were correctly identified in 88% of cases.Exhaled breath VOC profiling can accurately distinguish between patients with MM, ARDs and healthy controls. The CPA eNOSE is a novel method for distinguishing patients with MM. This could eventually translate into a screening tool for high risk populations. |
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Authors:
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E A Chapman; P S Thomas; E Stone; C Lewis; D H Yates |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-19 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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School of Medical Sciences, University of New South Wales, Kensington, Australia, 2052. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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