Document Detail


The breakpoint of the Philadelphia chromosome 22 in chronic myeloid leukaemia is distal to the immunoglobulin lambda light chain constant region genes.
MedLine Citation:
PMID:  6436636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Somatic cell hybrids containing chromosomes from a patient with chronic myeloid leukaemia were used as a source of DNA for filter hybridizations with immunoglobulin lambda light chain constant region and c-onc probes. The results show that at least part of the human lambda constant region locus remains on the abnormal chromosome 22 (the Philadelphia chromosome) and therefore that this translocation occurs distal to these genes. Further, in the patient studied the c-abl gene has been translocated to the abnormal chromosome 22, thus creating a new genetic linkage between C lambda and c-abl genes.
Authors:
T H Rabbitts; A Forster; J G Matthews
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular biology & medicine     Volume:  1     ISSN:  0735-1313     ISO Abbreviation:  Mol. Biol. Med.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1984-11-28     Completed Date:  1984-11-28     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8403879     Medline TA:  Mol Biol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  11-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosome Aberrations / genetics*
Chromosome Disorders
Chromosomes, Human, 21-22 and Y*
Cricetinae
Cricetulus
DNA, Neoplasm / genetics
Humans
Hybrid Cells / metabolism
Immunoglobulin Light Chains / genetics*
Immunoglobulin lambda-Chains / genetics*
Leukemia, Myeloid / genetics*
Nucleic Acid Hybridization
Translocation, Genetic
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/Immunoglobulin Light Chains; 0/Immunoglobulin lambda-Chains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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