Document Detail


The breadth and titer of maternal HIV-1-specific heterologous neutralizing antibodies are not associated with a lower rate of mother-to-child transmission of HIV-1.
MedLine Citation:
PMID:  22811522     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been hypothesized that neutralizing antibodies (NAbs) should have broad specificity to be effective in protection against diverse HIV-1 variants. The mother-to-child transmission model of HIV-1 provides the opportunity to examine whether the breadth of maternal NAbs is associated with protection of infants from infection. Samples were obtained at delivery from 57 transmitting mothers (T) matched with 57 nontransmitting mothers (NT) enrolled in the multicenter French perinatal cohort (ANRS EPF CO1) between 1990 and 1996. Sixty-eight (59.6%) and 46 (40.4%) women were infected by B and non-B viruses, respectively. Neutralization assays were carried out with TZM-bl cells, using a panel of 10 primary isolates of 6 clades (A, B, C, F, CRF01_AE, and CRF02_AG), selected for their moderate or low sensitivity to neutralization. Neutralization breadths were not statistically different between T and NT mothers. However, a few statistically significant differences were observed, with higher frequencies or titers of NAbs toward several individual strains for NT mothers when the clade B-infected or non-clade B-infected mothers were analyzed separately. Our study confirms that the breadth of maternal NAbs is not associated with protection of infants from infection.
Authors:
Antoine Chaillon; Thierry Wack; Martine Braibant; Laurent Mandelbrot; Stéphane Blanche; Josiane Warszawski; Francis Barin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-18
Journal Detail:
Title:  Journal of virology     Volume:  86     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-11     Completed Date:  2012-11-29     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10540-6     Citation Subset:  IM    
Affiliation:
Université François Rabelais, Inserm U966, Tours, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Neutralizing / chemistry*
Case-Control Studies
Cohort Studies
Female
HIV Antibodies / immunology
HIV Infections / immunology,  transmission*
HIV-1 / metabolism*
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
Male
Maternal Exposure
Mothers
Neutralization Tests / methods*
Pregnancy
Pregnancy Complications, Infectious / diagnosis*,  immunology
Chemical
Reg. No./Substance:
0/Antibodies, Neutralizing; 0/HIV Antibodies
Comments/Corrections

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