Document Detail


The brainstem and serotonin in the sudden infant death syndrome.
MedLine Citation:
PMID:  19400695     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sudden infant death syndrome (SIDS) is the sudden death of an infant under one year of age that is typically associated with sleep and that remains unexplained after a complete autopsy and death scene investigation. A leading hypothesis about its pathogenesis is that many cases result from defects in brainstem-mediated protective responses to homeostatic stressors occurring during sleep in a critical developmental period. Here we review the evidence for the brainstem hypothesis in SIDS with a focus upon abnormalities related to the neurotransmitter serotonin in the medulla oblongata, as these are the most robust pathologic findings to date. In this context, we synthesize the human autopsy data with genetic, whole-animal, and cellular data concerning the function and development of the medullary serotonergic system. These emerging data suggest an important underlying mechanism in SIDS that may help lead to identification of infants at risk and specific interventions to prevent death.
Authors:
Hannah C Kinney; George B Richerson; Susan M Dymecki; Robert A Darnall; Eugene E Nattie
Related Documents :
12856955 - Arsenic methylation by micro-organisms isolated from sheepskin bedding materials.
17091255 - Maternal smoking and sudden infant death syndrome: epidemiological study related to pat...
3589245 - Statistical analysis of heart rates in subsequent victims of sudden infant death syndrome.
2563105 - Sleeping position and infant bedding may predispose to hyperthermia and the sudden infa...
1843525 - Evidence for language-specific rhythmic influences in the reduplicative babbling of fre...
1677075 - Epidemic of caesarean sections in brazil.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annual review of pathology     Volume:  4     ISSN:  1553-4014     ISO Abbreviation:  Annu Rev Pathol     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-29     Completed Date:  2009-05-28     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  101275111     Medline TA:  Annu Rev Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  517-50     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Brain Stem / metabolism*,  pathology
Humans
Infant
Neurons / metabolism*,  pathology
Risk Assessment
Risk Factors
Serotonin / metabolism*
Sudden Infant Death / etiology*,  pathology,  prevention & control
Grant Support
ID/Acronym/Agency:
P01 HD 36379/HD/NICHD NIH HHS; P01 HD036379/HD/NICHD NIH HHS; P01 HD036379-11/HD/NICHD NIH HHS; P30 HD 18655/HD/NICHD NIH HHS; P30 HD018655-19/HD/NICHD NIH HHS; R01 HD020991/HD/NICHD NIH HHS; R01 HD020991-25/HD/NICHD NIH HHS; R01 HL028066/HL/NHLBI NIH HHS; R01 HL028066-29A1/HL/NHLBI NIH HHS; R37 HD 20991/HD/NICHD NIH HHS; R37 HL 28066/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
333DO1RDJY/Serotonin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regulation of hepcidin and iron-overload disease.
Next Document:  Molecular pathogenesis of cutaneous melanocytic neoplasms.