| The brain renin-angiotensin system modulates angiotensin II-induced hypertension and cardiac hypertrophy. | |
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MedLine Citation:
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PMID: 10642333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The potential involvement of the brain renin-angiotensin system in the hypertension induced by subpressor doses of angiotensin II was tested by the use of newly developed transgenic rats with permanent inhibition of brain angiotensinogen synthesis [TGR(ASrAOGEN)]. Basal systolic blood pressure monitored by telemetry was significantly lower in TGR(ASrAOGEN) than in Sprague-Dawley rats (parent strain) (122.5+/-1.5 versus 128.9+/-1.9 mm Hg, respectively; P<0.05). The increase in systolic blood pressure induced by 7 days of chronic angiotensin II infusion was significantly attenuated in TGR(ASrAOGEN) in comparison with control rats (29.8+/-4.2 versus 46. 3+/-2.5 mm Hg, respectively; P<0.005). Moreover, an increase in heart/body weight ratio was evident only in Sprague-Dawley (11.1%) but not in TGR(ASrAOGEN) rats (2.8%). In contrast, mRNA levels of atrial natriuretic peptide (ANP) and collagen III in the left ventricle measured by ribonuclease protection assay were similarly increased in both TGR(ASrAOGEN) (ANP, x2.5; collagen III, x1.8) and Sprague-Dawley rats (ANP, x2.4; collagen III, x2) as a consequence of angiotensin II infusion. Thus, the expression of these genes in the left ventricle seems to be directly stimulated by angiotensin II. However, the hypertensive and hypertrophic effects of subpressor angiotensin II are at least in part mediated by the brain renin-angiotensin system. |
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Authors:
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O Baltatu; J A Silva; D Ganten; M Bader |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension Volume: 35 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-02-07 Completed Date: 2000-02-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 409-12 Citation Subset: IM |
Affiliation:
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Max-Delbrück Center for Molecular Medicine, Berlin-Buch, Germany. baltatu@mdc-berlin.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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pharmacology Angiotensinogen / genetics* Animals Animals, Genetically Modified Atrial Natriuretic Factor / genetics Blood Pressure / drug effects Brain Chemistry / physiology* Cardiomegaly / chemically induced, physiopathology* Collagen / genetics Gene Expression / physiology Heart Ventricles / chemistry, drug effects, metabolism Hypertension, Renal / chemically induced, physiopathology* Male Myocardium / chemistry, metabolism RNA, Messenger / analysis Rats Rats, Sprague-Dawley Renin-Angiotensin System / physiology* |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 11002-13-4/Angiotensinogen; 11128-99-7/Angiotensin II; 85637-73-6/Atrial Natriuretic Factor; 9007-34-5/Collagen |
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