Document Detail

The brain and heart: dancing in unison?
MedLine Citation:
PMID:  19013442     Owner:  NLM     Status:  MEDLINE    
Coronary artery disease (CAD) and its main complication myocardial infarction are the leading causes of death globally. Environmental factors don't explain the large amount of variance seen in the development of the disease. Given the strong heritability of CAD, some of the unexplained variance may be due to genetic factors. In this issue of the Journal, Jiang and colleagues report a strong association between brain derived neurotrophic factor (BDNF) Val66Met polymorphism and CAD. There is increasing evidence that BDNF is not only involved in neuronal development but also energy expenditure. The results of this study are likely to give further impetus to researching the complex mechanisms and crosstalk that contribute to the pathogenesis of various polygenic disorders.
Rajiv T Erasmus
Publication Detail:
Type:  Comment; Editorial     Date:  2008-11-05
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  400     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-02     Completed Date:  2009-02-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-2     Citation Subset:  IM    
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MeSH Terms
Brain-Derived Neurotrophic Factor / genetics*,  metabolism*
Coronary Artery Disease / genetics*,  metabolism,  pathology,  physiopathology*
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor
Comment On:
Clin Chim Acta. 2009 Feb;400(1-2):3-7   [PMID:  19013140 ]

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