Document Detail

The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology.
MedLine Citation:
PMID:  15537879     Owner:  NLM     Status:  MEDLINE    
A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.
Lukas Pezawas; Beth A Verchinski; Venkata S Mattay; Joseph H Callicott; Bhaskar S Kolachana; Richard E Straub; Michael F Egan; Andreas Meyer-Lindenberg; Daniel R Weinberger
Related Documents :
12542259 - The interaction of rhinal cortex and hippocampus in human declarative memory formation.
10985279 - Cortico-hippocampal communication by way of parallel parahippocampal-subicular pathways.
15232109 - Sites of neocortical reorganization critical for remote spatial memory.
8922339 - The parahippocampus subserves topographical learning in man.
12488819 - Time-dependent contribution of the hippocampal complex when remembering the past: a pet...
9034849 - A theory of hippocampal function in memory.
2081399 - Hemispheric specialization in visual, tactile and crossmodal assembling tasks.
10462129 - Way 100635, a 5-ht1a receptor antagonist, prevents the impairment of spatial learning c...
24149069 - Pregnenolone sulphate enhances spatial orientation and object discrimination in adult m...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  24     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-11     Completed Date:  2005-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10099-102     Citation Subset:  IM    
Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1379, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acid Substitution*
Brain-Derived Neurotrophic Factor / genetics*,  physiology
Genetic Variation*
Hippocampus / ultrastructure*
Imaging, Three-Dimensional
Learning / physiology
Magnetic Resonance Imaging
Memory / physiology
Middle Aged
Neuronal Plasticity*
Organ Size
Polymorphism, Genetic
Prefrontal Cortex / ultrastructure*
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.
Next Document:  Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons.