Document Detail


The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology.
MedLine Citation:
PMID:  15537879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.
Authors:
Lukas Pezawas; Beth A Verchinski; Venkata S Mattay; Joseph H Callicott; Bhaskar S Kolachana; Richard E Straub; Michael F Egan; Andreas Meyer-Lindenberg; Daniel R Weinberger
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  24     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-11     Completed Date:  2005-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10099-102     Citation Subset:  IM    
Affiliation:
Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1379, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alleles
Amino Acid Substitution*
Brain-Derived Neurotrophic Factor / genetics*,  physiology
Female
Genetic Variation*
Hippocampus / ultrastructure*
Humans
Imaging, Three-Dimensional
Learning / physiology
Magnetic Resonance Imaging
Male
Memory / physiology
Middle Aged
Neuronal Plasticity*
Organ Size
Polymorphism, Genetic
Prefrontal Cortex / ultrastructure*
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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