Document Detail


The border zone in acute myocardial ischemia in the dog--a histochemical, biochemical and ultrastructural study.
MedLine Citation:
PMID:  6694329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To identify and characterize the border zone, anesthetized dogs were subjected to 1-hour occlusion of the left anterior descending coronary artery with (Group R) or without (Groups A and B) 2 hours of subsequent reperfusion. Histochemical analysis of glycogen distribution, biochemical determination of lactate and adenosine triphosphate (ATP), and ultrastructural examination were carried out. In Group A, the epicardial edge of cyanosis was clearly visible and the sharply demarcated glycogen-depleted area contained peninsulas of cells with varying amounts of glycogen in its epicardial half, which were suggested to depend on collateral blood flow by intracoronary dye injection. In Group B, the edge of cyanosis was obscure and the glycogen-depleted area contained above-mentioned peninsulas at its lateral edge also. In Group R, although the edge of cynaosis was clear on occlusion, the peninsulas were numerous at the lateral edge as well as in the subepicardium after reperfusion. Lactate accumulation and ATP degradation corresponded well to glycogen decrease in all groups and were reduced significantly by reperfusion (p less than 0.005). Ultrastructural examination confirmed these findings. Therefore epicardial, and in some cases also lateral, salvageable border zones may exist and be composed of peninsulas of normal and intermediately injured cells dependent on collateral blood flow.
Authors:
K Mitsunami; T Fukuhara; S Kato; K Bito; M Kinoshita; S Kawakita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese circulation journal     Volume:  48     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-03-05     Completed Date:  1984-03-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  18-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism*
Animals
Coronary Disease / metabolism*,  pathology
Dogs
Female
Glycogen / metabolism*
Histocytochemistry
Lactates / metabolism
Lactic Acid
Male
Myocardium / metabolism*,  ultrastructure
Chemical
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid; 56-65-5/Adenosine Triphosphate; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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