Document Detail

The border zone of the early myocardial infarction in dogs; its characteristics and viability.
MedLine Citation:
PMID:  6477385     Owner:  NLM     Status:  MEDLINE    
In open-chest dogs, the left anterior descending coronary artery was ligated for 150 min. The heart was semiserially cut on a cryomicrotome and areas of ischemic damage were visualized by means of glycogen depletion (PAS reaction) and tissue acidosis (a "sandwich" technique with pH indicator dispersed in a layer of gel). The extent of myocardial damage was determined morphometrically. The mass of the glycogen-depleted heart muscle was greater than the mass of the ischemic tissue detected by means of decreased pH (p less than 0.01). The border zone was characterized by glycogen depletion without acidosis. Circulation studies using intravital fluorescein staining have shown that perfusion is partially retained in the border zone; it is assumed that the hypoperfusion triggers glycogenolysis. Nevertheless, the level of perfusion suffices to wash out the acidic end products. Comparison of contrapulsation-treated dogs and untreated dogs shows that the amount of damaged tissue comprising the border zone can be reduced by this therapeutic intervention (p less than 0.02) - in contrast to the acidotic tissue, the amount of which is not significantly influenced. Therefore the border zone contains damaged but still viable muscle cells.
T Sládek; J Filkuka; S Dolezel; J Vasků; B Hartmannová; J Trávnícková
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Basic research in cardiology     Volume:  79     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:    1984 May-Jun
Date Detail:
Created Date:  1984-10-18     Completed Date:  1984-10-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  344-9     Citation Subset:  IM    
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MeSH Terms
Coronary Circulation
Glycogen / metabolism*
Hydrogen-Ion Concentration
Microscopy, Fluorescence
Myocardial Infarction / metabolism,  pathology*
Myocardium / metabolism,  pathology*
Reg. No./Substance:

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