| The bone-muscle ratio of fetal lambs is affected more by maternal nutrition during pregnancy than by maternal size. | |
| | |
MedLine Citation:
|
PMID: 18385462 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bone formation and loss are related to the strain imposed on bone by muscle forces. Bone mineral content (BMC) and lean mass (LM) of fetal lambs was determined at day 140 of pregnancy in 8 groups of ewes, which were of either large or small body size, on either high (ad libitum) or maintenance pasture intake from day 21 of pregnancy, or carrying either singletons or twins. BMC and LM (using DXA scanning) of fetal hindquarters/spine were corrected to leg length. BMC and LM were less in twin than singleton groups (P < 0.001). Large ewes on high intake produced single fetuses with a (group mean) BMC/LM ratio that was higher (P < 0.002) than that in fetuses of large ewes with singletons on maintenance intake or twins on either high or maintenance intakes, the ratios of which were not different. In single fetuses from small ewes on high intake, the BMC/LM ratio was higher than those from small ewes with singletons on maintenance intake or twins on either high or maintenance intakes, the ratios of which were not different. The ratio was not different in singleton fetuses of ewes on high intake, whether they were large or small. Different fetal environments resulted in a given amount of muscle being associated with a higher or lower bone mass. Dietary intake during pregnancy was more important than maternal size in affecting the ratio. We conclude that intrauterine environmental factors may be important in determining bone mass postnatally, and possibly later in life. |
| | |
Authors:
|
E C Firth; C W Rogers; M Vickers; P R Kenyon; C M C Jenkinson; H T Blair; P L Johnson; D D S Mackenzie; S W Peterson; S T Morris |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-02 |
Journal Detail:
|
Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 294 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-06-04 Completed Date: 2008-07-22 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: R1890-4 Citation Subset: IM |
Affiliation:
|
Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Tennant Drive, Palmerston North, New Zealand 4442. E.C.Firth@massey.ac.nz |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animal Nutritional Physiological Phenomena
/
physiology Animals Body Mass Index Body Size / physiology* Body Weight / physiology Bone Density / physiology Bone and Bones / anatomy & histology*, embryology, physiology Female Fetus / anatomy & histology*, physiology Maternal Nutritional Physiological Phenomena / physiology* Muscle Contraction / physiology Muscle, Skeletal / anatomy & histology*, embryology, physiology Organ Size / physiology Pregnancy Pregnancy, Animal / physiology* Sheep / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neonatal stem cells exhibit specific characteristics in function, proliferation, and cellular signal...
Next Document: Hepatic insulin resistance induced by prenatal alcohol exposure is associated with reduced PTEN and ...