Document Detail


The bone mass density in postmenopausal women using hormonal replacement therapy in relation to polymorphism in vitamin D receptor and estrogen receptor genes.
MedLine Citation:
PMID:  19903038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aims of the study were as follows: (1) To identify the differences in spinal body mass density (BMD) in relation to polymorphism in vitamin D receptor (VDR) and estrogen receptor-alpha (ERalpha) genes in untreated women with postmenopausal osteoporosis. (2) To assess the efficacy of treatment in women with postmenopausal osteoporosis in relation to polymorphism in VDR and ERalpha genes. (3) To find the estradiol concentration necessary to protect bone tissue in patients with a given polymorphism in VDR and ERalpha genes. METHODS: The study included 44 postmenopausal women with primary osteoporosis who used cyclic hormonal replacement therapy (HRT) for a year. The polymorphism of ERalpha and VDR genes were evaluated. We also determined the age, body mass index and spinal BMD before and after 12 months of administration the HRT. RESULTS: We found a significant spinal BMD increase, what is connected with ERalpha genotype and both VDR and ERalpha genes. There is no such a correlation observed in polymorphism of VDR gene. CONCLUSIONS: (1) There is no relationship between VDR and ERalpha genes polymorphism and the stage of osteoporosis related to the spinal BMD value before treatment. (2) The XX, PP or Bb markers or only X, P, B alleles are connected with a significant decrease of treatment efficacy. (3) Estradiol serum concentration before and during HRT is not dependent on the polymorphism of VDR and ERalpha genes.
Authors:
Agnieszka Brodowska; Andrzej Starczewski; Jacek Brodowski; Iwona Szyd??owska; Jolanta Nawrocka-Rutkowska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  25     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-11-11     Completed Date:  2010-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  315-23     Citation Subset:  IM    
Affiliation:
Department of Reproduction and Gynecology, Pomeranian Medical University of Szczecin, 71-010 Police, Siedlecka 2, Poland. fampiel@sci.pam.szczecin.p
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Bone Density / drug effects,  genetics*
Estradiol / administration & dosage
Estrogen Receptor alpha / genetics*
Estrogen Replacement Therapy*
Estrogens / administration & dosage
Female
Humans
Middle Aged
Osteoporosis, Postmenopausal / drug therapy,  physiopathology*
Polymorphism, Genetic
Receptors, Calcitriol / genetics*
Chemical
Reg. No./Substance:
0/Estrogen Receptor alpha; 0/Estrogens; 0/Receptors, Calcitriol; 50-28-2/Estradiol

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