| The bone anabolic carotenoids p-hydroxycinnamic acid and β-cryptoxanthin antagonize NF-κB activation in MC3T3 preosteoblasts. | |
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MedLine Citation:
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PMID: 21475879 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The carotene p-hydroxycinnamic acid and the xanthophyll β-cryptoxanthin are members of the carotenoid family of plant-derived pigments, which are endowed with anti-osteoporotic properties in vivo. p-Hydroxycinnamic acid and β-cryptoxanthin have been demonstrated to stimulate osteoblastic bone formation while simultaneously repressing osteoclastic bone resorption in vitro. However, their mechanisms of action remain poorly elucidated. It is well established that the NF-;kgr;B signal transduction pathway plays a critical role in osteoclast differentiation. Moreover, we recently demonstrated that NF-κB activity potently antagonizes osteoblastic differentiation and mineralization in vitro. In this study, we used transient transfection assays of a NF-κB luciferase reporter to demonstrate that p-hydroxycinnamic acid and β-cryptoxanthin antagonize NF-κB activation in MC3T3 preosteoblastic cells. The data obtained suggest that NF-κB may be a common molecular target by which several bone active agents, including carotenoids, promote osteoblastic bone formation. |
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Authors:
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Masayoshi Yamaguchi; M N Weitzmann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular medicine reports Volume: 2 ISSN: 1791-3004 ISO Abbreviation: Mol Med Report Publication Date: 2009 Jul-Aug |
Date Detail:
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Created Date: 2011-04-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101475259 Medline TA: Mol Med Report Country: Greece |
Other Details:
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Languages: eng Pagination: 641-4 Citation Subset: - |
Affiliation:
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Division of Endocrinology and Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322-0001, USA. yamamasa1155@yahoo.co.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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