Document Detail


The body composition and lipid metabolic effects of long-term ethanol feeding during a high omega 6 polyunsaturated fatty acid diet in micropigs.
MedLine Citation:
PMID:  8412749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our previous research with miniature pigs has shown that long-term ethanol feeding with a low-fat diet decreases arachidonic acid (20:4 omega 6) levels in multiple tissues, but we did not find significant liver pathology. In this study, we investigated the effect of ethanol feeding with high dietary linoleic acid (18:2 omega 6) on tissue fatty acid (FA) profiles and body composition. Five Yucatan micropigs were fed 370 kJ (89 kcal)/kg body weight of a diet containing ethanol and fat as 40% and 34% of energy, respectively; five control pigs were pair-fed corn starch in place of ethanol. Corn oil, 61% 18:2 omega 6, supplied most of the dietary fat. Liver biopsies were performed at baseline (n = 2 per group) and at three other time points (n = 5 per group). Phospholipid (PL) FA levels were measured by thin-layer and gas chromatography. Body composition was analyzed by underwater weighing of carcasses. Body composition analysis demonstrated a marked reduction of carcass fat in the ethanol group, but no significant reduction of carcass lean weight after 12 months. In liver PLs, the ethanol group showed decreased 20:4 omega 6 and docosahexaenoic acid (22:6 omega 3) after 1 month. While the decreased 20:4 omega 6 remained constant after 1 month, 22:6 omega 3 showed a progressive decrease up to 12-months, resulting in a continuous decrease of the omega 3/omega 6 FA ratio. This slowly progressive decrease in the omega 3/omega 6 ratio in liver PLs with ethanol feeding may have enhanced the inflammatory response in the liver, contributing to liver pathology. Body composition results indicate marked wasting of energy in the ethanol group.
Authors:
M T Nakamura; A B Tang; J Villanueva; C H Halsted; S D Phinney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  42     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-11-09     Completed Date:  1993-11-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1340-50     Citation Subset:  IM    
Affiliation:
Division of Clinical Nutrition and Metabolism, School of Medicine, University of California, Davis.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Biopsy
Body Composition / physiology*
Body Weight / physiology
Chromatography, Gas
Chromatography, Thin Layer
Diet
Ethanol / administration & dosage,  pharmacology*
Fatty Acids, Omega-6
Fatty Acids, Unsaturated / administration & dosage,  analysis,  pharmacology*
Lipid Metabolism*
Liver / chemistry,  pathology
Swine
Swine, Miniature / metabolism*
Time Factors
Grant Support
ID/Acronym/Agency:
35747//PHS HHS; 6938//PHS HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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