Document Detail


Is blood pressure really a trigger for the circadian rhythm of subarachnoid hemorrhage?
MedLine Citation:
PMID:  7570729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Circadian blood pressure changes are not infrequently cited as a trigger for the onset of subarachnoid hemorrhage (SAH). Our purpose was to determine the reliability of this chronorisk and study the variability and consequences of it as it occurs in hypertensive and normotensive individuals. METHODS: Of 273 consecutive patients with proven SAH of aneurysmal origin seen between January 1990 and December 1993, we studied 120 (44%) for whom the exact time of hemorrhage could be reliably determined. Beyond the recognition of a circadian rhythm for this collective, the patients were then sorted by blood pressure, yielding one group each of 80 normotensive (group N, 66.7%) and hypertensive (group H, 33.3%) individuals. The differential chronorisk of these two groups was studied. RESULTS: A circadian rhythm with a definitive characteristic acrophase was observed for the entire group, occurring between 9 AM and 10 AM (chi 2 test, P < .0005) with a possible secondary peak in the afternoon hours. The separation into two blood pressure groups somewhat surprisingly revealed a different curve for each group (chi 2 test, P = .01). Statistical analysis of each group's separate chronorisk revealed that this acrophase only holds true for hypertensive individuals, whereas normotensive patients not only lack a morning peak, but an apparent elevation in the afternoon is statistically irrelevant, leading to the impression that SAH in normotensive persons seems to be subject to no circadian rhythm at all. CONCLUSIONS: The incidence of SAH conforms to circadian blood pressure variation in hypertensive patients, similar to the diurnal rhythms observed with strokes and myocardial infarctions. This leads to the hypothesis that blood pressure elevation is a trigger for the onset of bleeding in this group. In clear contrast, normotensive individuals with cerebrovascular aneurysms seem to have a random 24-hour distribution of SAH onset times, thus leaving the nature of a possible trigger mechanism unresolved.
Authors:
G Kleinpeter; R Schatzer; F Böck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  26     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-11-02     Completed Date:  1995-11-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1805-10     Citation Subset:  IM    
Affiliation:
Neurochirurgische Abteilung, Donauspital, Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Blood Pressure*
Cerebrovascular Disorders / etiology,  physiopathology
Circadian Rhythm*
Cohort Studies
Female
Humans
Hypertension / complications,  physiopathology
Incidence
Intracranial Aneurysm / complications,  physiopathology
Male
Middle Aged
Myocardial Infarction / etiology,  physiopathology
Reproducibility of Results
Risk Factors
Subarachnoid Hemorrhage / etiology*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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