| Is blood the ideal submucosal cushioning agent? A comparative study in a porcine model. | |
| | |
MedLine Citation:
|
PMID: 17163324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND STUDY AIMS: Creation of a submucosal cushion before endoscopic mucosal resection (EMR) significantly reduces perforation risk. We evaluated six solutions as cushioning agents in live pigs. MATERIAL AND METHODS: 5 ml of normal saline, normal saline plus epinephrine, albumin 12.5 %, albumin 25 %, hydroxypropyl methylcellulose, and the pig's own whole blood were endoscopically injected into the porcine esophageal submucosa. Blood was obtained from a peripheral vein immediately before injection. Injections were made every 4 cm from the gastroesophageal junction. The time from completion of the injection to disappearance of the cushion was recorded. Endoscopy was repeated at 48 hours post injection. Two EMRs were performed after blood injection. Statistical analysis employed one-way analysis of variance followed by pairwise T test comparisons using the Bonferroni correction. RESULTS: Five animal experiments were completed. The mean time to dissipation of the submucosal cushion was shortest for saline plus epinephrine sites (2.87 minutes, SD 2.21) followed by the saline (4.8 minutes, SD 1.56), albumin 12.5 % (5.68 minutes, SD 3.48), albumin 25 % (7.83 minutes, SD 2.02), hydroxypropyl methylcellulose (9.77 minutes, SD 1.55), and blood sites (38.6 minutes, SD 6.07). Injection of blood resulted in significantly longer mucosal elevation than any other solution ( P < 0.0007). Blood from the cushion did not hamper visualization and facilitated EMR. CONCLUSION: Blood produces the most durable cushion compared with standard agents, also having the advantages of being readily available and without cost. Albumin 25 % provides as durable a cushion as hydroxypropyl methylcellulose. |
| | |
Authors:
|
S A Giday; P Magno; J M Buscaglia; M I Canto; C-W Ko; E J Shin; L Xia; L M Wroblewski; J O Clarke; A N Kalloo; S B Jagannath; S V Kantsevoy |
Related Documents
:
|
235794 - Effect of ischemic anoxia on myoelectrical and mechanical activity of the totally isola... 1249724 - Effects of isopropylnoradrenaline on tachyphylaxis of gastrin stimulated gastric acid s... 1443154 - Limitations of laser-doppler velocimetry and reflectance spectrophotometry in estimatin... 2944214 - Human gastric blood circulation evaluated by endoscopic laser doppler flowmetry. 1553214 - Gaze-induced amaurosis from central retinal artery compression. 12679724 - Regional cerebral blood flow and bold responses in conscious and anesthetized rats unde... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Endoscopy Volume: 38 ISSN: 0013-726X ISO Abbreviation: Endoscopy Publication Date: 2006 Dec |
Date Detail:
|
Created Date: 2006-12-13 Completed Date: 2007-02-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0215166 Medline TA: Endoscopy Country: Germany |
Other Details:
|
Languages: eng Pagination: 1230-4 Citation Subset: IM |
Affiliation:
|
Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD 21205, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Albumins
/
administration & dosage Animals Blood Transfusion, Autologous / methods* Esophagus Injections Methylcellulose / administration & dosage, analogs & derivatives Models, Animal Mucous Membrane* Swine Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Albumins; 8063-82-9/hypromellose; 9004-67-5/Methylcellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In vitro evaluation of forces exerted by a new computer-assisted colonoscope (the NeoGuide Endoscopy...
Next Document: Primary precutting versus conventional over-the-wire sphincterotomy for bile duct access: a prospect...