| The blood flow patterns of microsurgical procedures in rats with topical and systemic vasodilators. | |
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MedLine Citation:
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PMID: 9785427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The change in blood flow after anastomosis and the effects on the anastomosed artery of different classes of vasodilators such as lidocaine and chlorpromazine given topically (n = 10 in each group), and prostaglandin E1 (PGE1)(n = 12) and diltiazem hydrochloride (n = 10) given systemically, were investigated in the femoral arteries of rats. The blood flow after anastomosis decreased by 45%-60% compared with that before the anastomosis. Lidocaine showed almost the same pattern of blood flow as chlorpromazine. The former dilated the diameter of the vessel less than the latter, and the depression of the heart rate was less with lidocaine than in chlorpromazine. PGE1 had a longer and stronger vasodilatative action than diltiazem, and resulted in a remarkable increase in blood flow. Clinically, the topical application of chlorpromazine or lidocaine is recommended during an operation, and PGE1 should be given systemically after an operation to obtain adequate blood flow. |
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Authors:
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H W Notodihardjo; Y Ogawa; K Kusumoto |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi Volume: 32 ISSN: 0284-4311 ISO Abbreviation: Scand J Plast Reconstr Surg Hand Surg Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-12-11 Completed Date: 1998-12-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8707869 Medline TA: Scand J Plast Reconstr Surg Hand Surg Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 249-54 Citation Subset: IM |
Affiliation:
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Department of Plastic and Reconstructive Surgery, Kansai Medical University, Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Alprostadil / administration & dosage, pharmacology Analysis of Variance Anastomosis, Surgical Anesthetics, Local / administration & dosage, pharmacology Animals Chlorpromazine / administration & dosage, pharmacology Diltiazem / administration & dosage, pharmacology Dopamine Antagonists / administration & dosage, pharmacology Femoral Artery / physiology, surgery* Laser-Doppler Flowmetry Lidocaine / administration & dosage, pharmacology Male Microsurgery* Rats Rats, Wistar Regional Blood Flow / drug effects Vasodilator Agents / administration & dosage*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Dopamine Antagonists; 0/Vasodilator Agents; 137-58-6/Lidocaine; 42399-41-7/Diltiazem; 50-53-3/Chlorpromazine; 745-65-3/Alprostadil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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