Document Detail


The blood-brain barrier in health and disease.
MedLine Citation:
PMID:  23280789     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The blood-brain barrier (BBB) is a term used to describe a series of properties possessed by the vasculature of the central nervous system (CNS) that tightly regulate the movement of ions, molecules, and cells between the blood and the CNS. This barrier is crucial to provide the appropriate environment to allow for proper neural function, as well as protect the CNS from injury and disease. In this review, I discuss the cellular and molecular composition of the BBB and how the development and function of the BBB is regulated by interactions with the CNS microenvironment. I further discuss what is known about BBB dysfunction during CNS injury and disease, as well as methodology used to deliver drugs across the BBB to the CNS. ANN NEUROL 2012;72:648-672.
Authors:
Richard Daneman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  72     ISSN:  1531-8249     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2013-01-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  648-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Neurological Association.
Affiliation:
Department of Anatomy, University of California, San Francisco, San Francisco, CA. richard.daneman@ucsf.edu.
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