Document Detail

The blood-brain barrier following experimental subarachnoid hemorrhage. Part 1: Response to insult caused by arterial hypertension.
MedLine Citation:
PMID:  6827318     Owner:  NLM     Status:  MEDLINE    
In three groups of cats, the authors studied the effect of subarachnoid hemorrhage (SAH) on the permeability of the blood-brain barrier (BBB) to the penetration of Evans blue-protein complex. One group received arterial hypertension alone, one group SAH alone, and one group SAH followed by arterial hypertension. Animals subjected to arterial hypertension alone showed areas of BBB breakdown. However, when cats were rendered hypertensive after SAH, there were no demonstrable BBB lesions. The SAH was produced by intracisternal injection of whole blood and hypertension by the intravenous injection of metaraminol. The preservation of the BBB after SAH is discussed. Vasospasm is considered as a possible hemodynamic variable responsible for the protection of the BBB from hypertensive damage. The need for a new model is proposed to further investigate the state of the BBB after SAH.
E W Peterson; E R Cardoso
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  58     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  338-44     Citation Subset:  AIM; IM    
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MeSH Terms
Blood-Brain Barrier*
Brain / pathology
Capillary Permeability
Evans Blue / diagnostic use
Hypertension / physiopathology*
Subarachnoid Hemorrhage / physiopathology*
Reg. No./Substance:
314-13-6/Evans Blue

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