Document Detail


The blood-brain barrier following experimental subarachnoid hemorrhage. Part 2: Response to mercuric chloride infusion.
MedLine Citation:
PMID:  6219189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Under controlled physiological conditions, fresh blood was injected into the cisterna magna of 10 adult cats to produce subarachnoid hemorrhage (SAH). Damage to the blood-brain barrier (BBB) was induced 30 minutes after SAH by the intracarotid injection of a 6 x 10(-5)M solution of mercuric chloride (HgCl2). A control series of five cats received the same injection of HgCl2. Intravenously injected Evans blue dye was used to indicate areas of BBB damage. The lesions were confirmed by fluorescence microscopy. All control animals showed BBB damage in the hemisphere injected with HgCl2. Of the animals in the test group with SAH, 90% were free from lesions. When lesions were present, the distribution differed from that in the control group. These results bear a similarity to the reported absence of HgCl2 lesions during the acute stages after total cerebral ischemia. This suggests that the cellular components of the BBB participate in a general metabolic inhibition following SAH.
Authors:
E W Peterson; E R Cardoso
Related Documents :
12816269 - Regional cerebral blood flow monitoring in the diagnosis of delayed ischemia following ...
2118949 - Transcranial doppler ultrasound studies of cerebral autoregulation and subarachnoid hem...
20589869 - Sensory alien hand syndrome in corticobasal degeneration: a cerebral blood flow study.
929659 - Experimental cerebral vasospasm after subarachnoid hemorrhage: development and degree o...
11546889 - Effect of age on cerebral blood flow velocity and incidence of vasospasm after aneurysm...
7660409 - Hemorheological and hemodynamic analysis of hypervolemic hemodilution therapy for cereb...
24186609 - Suicide.
7892969 - Blood loss and transfusion requirements in liver transplantation: experience with the f...
21083009 - Transfusion medicine in trauma patients.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  58     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  345-51     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood-Brain Barrier / drug effects*
Brain / pathology
Capillary Permeability / drug effects
Cats
Endothelium
Evans Blue / diagnostic use
Mercuric Chloride
Mercury / pharmacology*
Subarachnoid Hemorrhage / physiopathology*
Chemical
Reg. No./Substance:
314-13-6/Evans Blue; 7439-97-6/Mercury; 7487-94-7/Mercuric Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Moon illusion and spiral aftereffect: illusions due to the loom-zoom system?
Next Document:  A new method for measuring cerebrospinal fluid flow in shunts.