Document Detail


The blood-brain barrier and brain drug delivery.
MedLine Citation:
PMID:  17048477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present report encompasses a thorough review of drug delivery to the brain with a particular focus on using drug carriers such as liposomes and nanoparticles. Challenges in brain drug delivery arise from the presence of one of the strictest barriers in vivo-the blood-brain barrier (BBB). This barrier exists at the level of endothelial cells of brain vasculature and its role is to maintain brain homeostasis. To better understand the principles of brain drug delivery, relevant knowledge of the blood-brain barrier anatomy and physiology is briefly reviewed. Several approaches to overcome the BBB have been reviewed including the use of carrier systems. In addition, strategies to enhance brain drug delivery by specific brain targeting are discussed.
Authors:
J M Koziara; P R Lockman; D D Allen; R J Mumper
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of nanoscience and nanotechnology     Volume:  6     ISSN:  1533-4880     ISO Abbreviation:  J Nanosci Nanotechnol     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-10-19     Completed Date:  2006-12-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101088195     Medline TA:  J Nanosci Nanotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2712-35     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0082, USA.
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MeSH Terms
Descriptor/Qualifier:
Blood-Brain Barrier / metabolism*
Brain / metabolism*
Coated Materials, Biocompatible / chemistry*
Drug Carriers / chemistry*
Drug Delivery Systems / methods*
Nanostructures / chemistry*
Pharmacokinetics*
Chemical
Reg. No./Substance:
0/Coated Materials, Biocompatible; 0/Drug Carriers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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