| The blood-brain barrier and brain drug delivery. | |
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MedLine Citation:
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PMID: 17048477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present report encompasses a thorough review of drug delivery to the brain with a particular focus on using drug carriers such as liposomes and nanoparticles. Challenges in brain drug delivery arise from the presence of one of the strictest barriers in vivo-the blood-brain barrier (BBB). This barrier exists at the level of endothelial cells of brain vasculature and its role is to maintain brain homeostasis. To better understand the principles of brain drug delivery, relevant knowledge of the blood-brain barrier anatomy and physiology is briefly reviewed. Several approaches to overcome the BBB have been reviewed including the use of carrier systems. In addition, strategies to enhance brain drug delivery by specific brain targeting are discussed. |
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Authors:
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J M Koziara; P R Lockman; D D Allen; R J Mumper |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of nanoscience and nanotechnology Volume: 6 ISSN: 1533-4880 ISO Abbreviation: J Nanosci Nanotechnol Publication Date: 2006 Sep-Oct |
Date Detail:
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Created Date: 2006-10-19 Completed Date: 2006-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101088195 Medline TA: J Nanosci Nanotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 2712-35 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0082, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood-Brain Barrier
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metabolism* Brain / metabolism* Coated Materials, Biocompatible / chemistry* Drug Carriers / chemistry* Drug Delivery Systems / methods* Nanostructures / chemistry* Pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Coated Materials, Biocompatible; 0/Drug Carriers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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