| The blood-brain barrier: connecting the gut and the brain. | |
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MedLine Citation:
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PMID: 18486244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The BBB prevents the unrestricted exchange of substances between the central nervous system (CNS) and the blood. The blood-brain barrier (BBB) also conveys information between the CNS and the gastrointestinal (GI) tract through several mechanisms. Here, we review three of those mechanisms. First, the BBB selectively transports some peptides and regulatory proteins in the blood-to-brain or the brain-to-blood direction. The ability of GI hormones to affect functions of the BBB, as illustrated by the ability of insulin to alter the BBB transport of amino acids and drugs, represents a second mechanism. A third mechanism is the ability of GI hormones to affect the secretion by the BBB of substances that themselves affect feeding and appetite, such as nitric oxide and cytokines. By these and other mechanisms, the BBB regulates communications between the CNS and GI tract. |
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Authors:
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William A Banks |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-04-07 |
Journal Detail:
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Title: Regulatory peptides Volume: 149 ISSN: 0167-0115 ISO Abbreviation: Regul. Pept. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-14 Completed Date: 2008-11-18 Revised Date: 2012-01-11 |
Medline Journal Info:
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Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: Netherlands |
Other Details:
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Languages: eng Pagination: 11-4 Citation Subset: IM |
Affiliation:
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GRECC, Veterans Affairs Medical Center-St. Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, WAB, 915 N. Grand Blvd, St. Louis, MO 63106, USA. bankswa@slu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / physiology Blood-Brain Barrier / metabolism*, physiology Brain / metabolism* Central Nervous System / metabolism* Gastrointestinal Tract / metabolism* Ghrelin / metabolism Humans Insulin / metabolism Leptin / metabolism Models, Biological Peptide Hormones / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG029839-01A1/AG/NIA NIH HHS; R01 AG029839-05/AG/NIA NIH HHS; R01 NS050547-03/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ghrelin; 0/Insulin; 0/Leptin; 0/Peptide Hormones |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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