| The blood-brain barrier, chemokines and multiple sclerosis. | |
| | |
MedLine Citation:
|
PMID: 20692338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The infiltration of leukocytes into the central nervous system (CNS) is an essential step in the neuropathogenesis of multiple sclerosis (MS). Leukocyte extravasation from the bloodstream is a multistep process that depends on several factors including fluid dynamics within the vasculature and molecular interactions between circulating leukocytes and the vascular endothelium. An important step in this cascade is the presence of chemokines on the vascular endothelial cell surface. Chemokines displayed along the endothelial lumen bind chemokine receptors on circulating leukocytes, initiating intracellular signaling that culminates in integrin activation, leukocyte arrest, and extravasation. The presence of chemokines at the endothelial lumen can help guide the movement of leukocytes through peripheral tissues during normal immune surveillance, host defense or inflammation. The expression and display of homeostatic or inflammatory chemokines therefore critically determine which leukocyte subsets extravasate and enter the peripheral tissues. Within the CNS, however, infiltrating leukocytes that cross the endothelium face additional boundaries to parenchymal entry, including the abluminal presence of localizing cues that prevent egress from perivascular spaces. This review focuses on the differential display of chemokines along endothelial surfaces and how they impact leukocyte extravasation into parenchymal tissues, especially within the CNS. In particular, the display of chemokines by endothelial cells of the blood brain barrier may be altered during CNS autoimmune disease, promoting leukocyte entry into this immunologically distinct site. Recent advances in microscopic techniques, including two-photon and intravital imaging have provided new insights into the mechanisms of chemokine-mediated capture of leukocytes within the CNS. |
| | |
Authors:
|
David W Holman; Robyn S Klein; Richard M Ransohoff |
Related Documents
:
|
21310418 - Effect of non-newtonian and pulsatile blood flow on mass transport in the human aorta. 2921298 - The effect of a low ph saline perfusate upon the integrity of the energy-depleted rat b... 14745458 - Identification of a novel route of iron transcytosis across the mammalian blood-brain b... 9886678 - Transport of brain-derived neurotrophic factor across the blood-brain barrier. 8045828 - Hemodynamics in the abdominal aorta: a comparison of in vitro and in vivo measurements. 10620258 - Chemical and rheological properties of an extracellular polysaccharide produced by the ... |
Publication Detail:
|
Type: Journal Article; Review Date: 2010-08-06 |
Journal Detail:
|
Title: Biochimica et biophysica acta Volume: 1812 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2010-12-20 Completed Date: 2011-03-01 Revised Date: 2012-02-02 |
Medline Journal Info:
|
Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 220-30 Citation Subset: IM |
Copyright Information:
|
2010 Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood-Brain Barrier / immunology, physiology* Cell Movement Chemokines / immunology, physiology* Endothelium / immunology, physiology Humans Immunity, Innate Leukocytes / immunology, physiology Lymphoid Tissue / immunology, physiology Models, Immunological Models, Neurological Multiple Sclerosis / etiology*, immunology Receptors, Chemokine / immunology, physiology |
| Grant Support | |
ID/Acronym/Agency:
|
P01 NS059560-020002/NS/NINDS NIH HHS; R01 NS052632-07/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Chemokines; 0/Receptors, Chemokine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of lysine modification on the stability and cellular binding of human amyloidogenic light cha...
Next Document: The mechanism underlying the appearance of late apoptotic neutrophils and subsequent TNF-? productio...