| A blind, controlled study of occipital cerebral asymmetry in schizophrenia. | |
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MedLine Citation:
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PMID: 6140697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a computed tomography (CT) study, scans from 45 schizophrenic patients on an acute treatment research ward and 62 headache control subjects were blindly compared. A reliable two-dimensional measure of occipital asymmetry did not detect any differences between the two groups. Within the patient sample, however, both a correlational and group analysis indicated that absence of normal left occipital asymmetry was associated with greater psychopathology on measures of quality of interview, incomprehensibility, and auditory hallucinations. Other clinical variables including age, years of illness, previous hospitalizations, childhood adjustment, and therapeutic response to neuroleptics were not found to be related to occipital asymmetry. A relationship between absence of normal asymmetry and abnormalities of language and communication is hypothesized. Furthermore, since the original studies that noted an increased frequency of reversed asymmetry in schizophrenic patients studied populations with a very high frequency of other CT abnormalities (e.g., enlarged lateral ventricles) and this study did not, the importance of defining the relevant characteristics of schizophrenic patients with reversed occipital asymmetry is emphasized. |
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Authors:
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D J Luchins; H Y Meltzer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Psychiatry research Volume: 10 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1984-02-14 Completed Date: 1984-02-14 Revised Date: 2008-04-17 |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 87-95 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipsychotic Agents / therapeutic use Chronic Disease Dominance, Cerebral / physiology* Humans Occipital Lobe / pathology* Prognosis Schizophrenia / drug therapy, pathology* Schizophrenic Psychology Tomography, X-Ray Computed* |
| Grant Support | |
ID/Acronym/Agency:
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MH-30938/MH/NIMH NIH HHS; MH-47808/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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