Document Detail

The bleach microscopy method and case detection for tuberculosis control.
MedLine Citation:
PMID:  16562703     Owner:  NLM     Status:  MEDLINE    
The World Health Organization (WHO) and the International Union Against Tuberculosis and Lung Disease (The Union) recommend direct sputum smear microscopy for tuberculosis (TB) case finding in resource-poor settings. This method is associated with poor sensitivity. Digestion of sputum with bleach prior to smear preparation has been reported to increase sensitivity. Some workers, having reviewed the relevant literature, have called for the WHO and The Union to advocate for a shift to this methodology for TB case finding. This article highlights deficiencies in the scope and detail of available evidence, and cautions against the premature, and possibly counter-productive, adoption of so-called 'bleach microscopy'. Further well-guided research is required to answer policy-relevant gaps in our knowledge about this promising technology.
A Ramsay; S B Squire; K Siddiqi; J Cunningham; M D Perkins
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  10     ISSN:  1027-3719     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-27     Completed Date:  2006-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  256-8     Citation Subset:  IM    
UNICEF/United Nations Development Programme/World Bank/World Health Organization Special Programme on Research and Training for Tropical Diseases (TDR), Geneva, Switzerland.
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MeSH Terms
Hypochlorous Acid / diagnostic use*
Microscopy / methods
Oxidants / diagnostic use*
Sputum / cytology*
Tuberculosis / diagnosis*,  prevention & control*
World Health Organization
Reg. No./Substance:
0/Oxidants; 7790-92-3/Hypochlorous Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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