| Febuxostat for gout. | |
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MedLine Citation:
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PMID: 20631196 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Around 1.4% of the UK population have gout, the prevalence of which increases with age to around 3% in women and 7% in men aged over 75 years. Acute gout is intensely painful and can reduce patients' quality of life. It occurs when the serum uric acid concentration (SUA) rises (hyperuricaemia) and persists above the solubility threshold of monosodium urate (400 micromol/L [6.8 mg/dL]), leading to urate crystal formation that causes arthritis, gouty tophi (nodules) in subcutaneous tissues and renal calculi. The mainstay of treatment for chronic gout is allopurinol, which inhibits xanthine oxidase (an enzyme involved in the production of uric acid in the body). However, this drug has to be stopped in a minority of patients due to rashes or hypersensitivity. Febuxostat (Adenuric - Menarini/Ipsen), another xanthine oxidase inhibitor, is a newly licensed treatment for chronic hyperuricaemia in conditions where urate deposition has occurred. Here we consider its place for patients with gout. |
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Authors:
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Drug and therapeutics bulletin Volume: 48 ISSN: 0012-6543 ISO Abbreviation: Drug Ther Bull Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0112037 Medline TA: Drug Ther Bull Country: England |
Other Details:
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Languages: eng Pagination: 78-82 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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