Document Detail

Febuxostat for gout.
MedLine Citation:
PMID:  20631196     Owner:  NLM     Status:  In-Process    
Around 1.4% of the UK population have gout, the prevalence of which increases with age to around 3% in women and 7% in men aged over 75 years. Acute gout is intensely painful and can reduce patients' quality of life. It occurs when the serum uric acid concentration (SUA) rises (hyperuricaemia) and persists above the solubility threshold of monosodium urate (400 micromol/L [6.8 mg/dL]), leading to urate crystal formation that causes arthritis, gouty tophi (nodules) in subcutaneous tissues and renal calculi. The mainstay of treatment for chronic gout is allopurinol, which inhibits xanthine oxidase (an enzyme involved in the production of uric acid in the body). However, this drug has to be stopped in a minority of patients due to rashes or hypersensitivity. Febuxostat (Adenuric - Menarini/Ipsen), another xanthine oxidase inhibitor, is a newly licensed treatment for chronic hyperuricaemia in conditions where urate deposition has occurred. Here we consider its place for patients with gout.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug and therapeutics bulletin     Volume:  48     ISSN:  0012-6543     ISO Abbreviation:  Drug Ther Bull     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0112037     Medline TA:  Drug Ther Bull     Country:  England    
Other Details:
Languages:  eng     Pagination:  78-82     Citation Subset:  IM    
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