Document Detail


The bitter taste of infection.
MedLine Citation:
PMID:  23041625     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human innate immune response to pathogens is complex, and it has been difficult to establish the contribution of epithelial signaling in the prevention of upper respiratory tract infection. The prevalence of chronic sinusitis in the absence of systemic immune defects indicates that there may be local defects in innate immunity associated with such mucosal infections. In this issue of the JCI, Cohen and colleagues investigate the role of the bitter taste receptors in airway epithelial cells, and find that these are critical to sensing the presence of invading pathogens.
Authors:
Alice Prince
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Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-08
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-01     Completed Date:  2013-01-15     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3847-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Columbia University, New York, New York 10032, USA. asp7@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Female
Genetic Predisposition to Disease*
Humans
Male
Nasal Mucosa*
Paranasal Sinuses*
Polymorphism, Genetic*
Pseudomonas Infections*
Pseudomonas aeruginosa*
Receptors, G-Protein-Coupled*
Rhinitis*
Grant Support
ID/Acronym/Agency:
HL73989/HL/NHLBI NIH HHS; R01HL079395/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, G-Protein-Coupled; 0/taste receptors, type 2
Comments/Corrections
Comment On:
J Clin Invest. 2012 Nov 1;122(11):4145-59   [PMID:  23041624 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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