Document Detail

A bird's-eye view of cell therapy and tissue engineering for cardiac regeneration.
MedLine Citation:
PMID:  22548570     Owner:  NLM     Status:  MEDLINE    
Complete recovery of ischemic cardiac muscle after myocardial infarction is still an unresolved concern. In recent years, intensive research efforts have focused on mimicking the physical and biological properties of myocardium for cardiac repair. Here we show how heart regeneration approaches have evolved from cell therapy to refined tissue engineering. Despite progressive improvements, the best cell type and delivery strategy are not well established. Our group has identified a new population of cardiac adipose tissue-derived progenitor cells with inherent cardiac and angiogenic potential that is a promising candidate for cell therapy to restore ischemic myocardium. We also describe results from three strategies for cell delivery into a murine model of myocardial infarction: intramyocardial injection, implantation of a fibrin patch loaded with cells, and an engineered bioimplant (a combination of chemically designed scaffold, peptide hydrogel, and cells); dual-labeling noninvasive bioluminescence imaging enables in vivo monitoring of cardiac-specific markers and cell survival.
Carolina Soler-Botija; Juli R Bagó; Antoni Bayes-Genis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1254     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-05-02     Completed Date:  2012-06-28     Revised Date:  2012-12-06    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  57-65     Citation Subset:  IM    
Copyright Information:
© 2012 New York Academy of Sciences.
Heart Failure and Cardiac Regeneration (ICREC) Research Program, Health Research Institute Germans Trias i Pujol (IGTP), Cardiology Service, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
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MeSH Terms
Adipocytes / transplantation
Cardiomyoplasty / methods
Cell Transplantation / methods*
Fibrin Tissue Adhesive / therapeutic use
Heart / physiology*
Myocardial Infarction / physiopathology,  therapy
Regeneration / physiology*
Tissue Engineering / methods*
Reg. No./Substance:
0/Fibrin Tissue Adhesive
Erratum In:
Ann N Y Acad Sci. 2012 Oct;1270:121

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