Document Detail

A bird's-eye view of autophagy.
MedLine Citation:
PMID:  23615436     Owner:  NLM     Status:  MEDLINE    
Autophagy is a process in which a eukaryotic (but not prokaryotic) cell destroys its own components through the lysosomal machinery. This tightly regulated process is essential for normal cell growth, development, and homeostasis, serving to maintain a balance between synthesis and degradation, resulting in the recycling of cellular products. Here we try to expand the concept of autophagy and define it as a general mechanism of regulation encompassing various levels of the biosphere. Interestingly, one of the consequences of such an approach is that we must presume an existence of the autophagic processes in the prokaryotic domain.
Petro Starokadomskyy; Kostyantyn V Dmytruk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-04-15
Journal Detail:
Title:  Autophagy     Volume:  9     ISSN:  1554-8635     ISO Abbreviation:  Autophagy     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-10-24     Completed Date:  2014-04-03     Revised Date:  2014-07-01    
Medline Journal Info:
Nlm Unique ID:  101265188     Medline TA:  Autophagy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1121-6     Citation Subset:  IM    
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MeSH Terms
Eukaryotic Cells / cytology
Models, Biological
Prokaryotic Cells / cytology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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