| Is bipolar disorder an inflammatory condition? The relevance of microglial activation. | |
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MedLine Citation:
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PMID: 23196997 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Literature published over the past few years indicates that bipolar disorder has an inflammatory component but does not explicitly define bipolar disorder as an inflammatory or a noninflammatory condition. RECENT FINDINGS: Recent studies have shown that bipolar disorder involves microglial activation and alterations in peripheral cytokines and have pointed to the efficacy of adjunctive anti-inflammatory therapies in bipolar depression. SUMMARY: The presence of active microglia and increased proinflammatory cytokines in bipolar disorder suggests an important role of inflammatory components in the pathophysiology of the disease, as well as a possible link between neuroinflammation and peripheral toxicity. |
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Authors:
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Laura Stertz; Pedro V S Magalhães; Flávio Kapczinski |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in psychiatry Volume: 26 ISSN: 1473-6578 ISO Abbreviation: Curr Opin Psychiatry Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809880 Medline TA: Curr Opin Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 19-26 Citation Subset: IM |
Affiliation:
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aLaboratory of Molecular Psychiatry, Centro de Pesquisas Experimentais, Hospital de Clínicas de Porto Alegre, and INCT for Translational Medicine bPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Universidade Federal do Rio Grande do Sul, UFRGS cPrograma de Pós-Graduação em Medicina: Psiquiatria, Universidade Federal do Rio Grande do Sul, UFRGS, Brazil. |
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