Document Detail

The "ON"-bipolar agonist, L-2-amino-4-phosphonobutyrate, blocks light-evoked cone contraction in xenopus eye cups.
MedLine Citation:
PMID:  1538827     Owner:  NLM     Status:  MEDLINE    
Rhythmic photoreceptor metabolism in relationship to light-dark cycles is now thought to be regulated through a retinal feed-back mechanism with dopamine serving as a principal signal initiating light-evoked events. In order to test the hypothesis that depolarizing "ON"-bipolar neurons participate in the retinal signalling pathway, we determined the effects of L-2-amino-4-phosphonobutyrate (L-APB) on light-evoked cone contraction in eye cups from Xenopus laevis. L-APB blocked the response stereospecifically when applied over a broad concentration range. The high specificity of L-APB in retina suggests that sign-inverting bipolar neurons which depolarize in light are in the signalling pathway. One possibility is that this pathway conveys signals that regulate dopamine release.
J C Besharse
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurochemical research     Volume:  17     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-04-02     Completed Date:  1992-04-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  75-80     Citation Subset:  IM    
Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City 66103.
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MeSH Terms
Aminobutyric Acids / pharmacology*
Dopamine / metabolism,  pharmacology
Dopamine Antagonists
Photoreceptor Cells / drug effects*,  physiology
Signal Transduction
Xenopus laevis
Grant Support
Reg. No./Substance:
0/Aminobutyric Acids; 0/Dopamine Antagonists; 6323-99-5/2-amino-4-phosphonobutyric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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