| A biphasic model for sinusoidal liver perfusion remodeling after outflow obstruction. | |
| | |
MedLine Citation:
|
PMID: 20066463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Liver resection can lead to focal outflow obstruction due to transection of hepatic veins. Outflow obstruction may cause additional damage to the small remnant liver. Drainage of the obstructed territories is reestablished via dilatation of sinusoids. Subsequently, sinusoidal canals are formed draining the blood from the obstructed territory to the neighboring unobstructed territories. We raised the phenomenological hypothesis that the blood pressure gradient is the main driving force for the formation of sinusoidal vascular canals. We generated a biphasic mechanical model to describe this vascular remodeling process in relation to the variable pressure gradient. Therefore, we introduced a transverse isotropic permeability relation as well as an evolutional optimization rule to describe the relationship between pressure gradient and the direction of the sinusoidal blood flow in the fluid phase. As a next step, we developed a framework for the calculation concept including the representation of the governing weak formulations. Then, we examined a representative numerical example with simulation of the blood flow under both conditions, the physiological situation as well as after outflow obstruction. Doing so, we were able to reproduce numerically the experimentally observed process of reestablishing hepatic venous drainage via redirection of blood flow and formation of new vascular structures in respect to the fluid flow. The calculated results support the hypothesis that the reorientation of blood flow mainly depends on the pressure gradient. Further investigations are needed to determine the micromechanical influences on the reorientation of the sinusoids. |
| | |
Authors:
|
Tim Ricken; Uta Dahmen; Olaf Dirsch |
Related Documents
:
|
2229453 - Estimation of hepatic blood flow in branches of hepatic vessels utilizing a noninvasive... 16830083 - Redirection of the hepatic venous flow for the treatment of pulmonary arteriovenous mal... 10065953 - Capillary electrochromatography with segmented capillaries for controlling electroosmot... |
Publication Detail:
|
Type: Journal Article Date: 2010-01-12 |
Journal Detail:
|
Title: Biomechanics and modeling in mechanobiology Volume: 9 ISSN: 1617-7940 ISO Abbreviation: Biomech Model Mechanobiol Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-13 Completed Date: 2011-01-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101135325 Medline TA: Biomech Model Mechanobiol Country: Germany |
Other Details:
|
Languages: eng Pagination: 435-50 Citation Subset: IM; S |
Affiliation:
|
University of Duisburg-Essen, Essen, Germany. tim.ricken@uni-due.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Hepatic Veno-Occlusive Disease / physiopathology* Humans Liver Circulation / physiology* Models, Animal Models, Biological* Perfusion Rats |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of trabecular bone behavior in core and whole bone samples using high-resolution modeling...
Next Document: On the multiscale modeling of heart valve biomechanics in health and disease.