Document Detail

A biostatistical insight into the As(2)O(3) high dilution effects on the rate and variability of wheat seedling growth.
MedLine Citation:
PMID:  16230857     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Most criticism of homeopathy concerns the lack of scientific bases and theoretical models. Fundamental research could make important contributions to our understanding of the mechanisms of action of homeopathic treatments. Plant-based bioassays are suitable for basic research -- lacking the placebo effect and ensuring large data samples for structured statistical analyses. OBJECTIVE: The aim of this study was to reproduce a previous experiment on the effects of arsenic trioxide (As(2)O(3)) high dilutions on wheat seedling growth in order to verify whether the same significant results could be obtained working in a different place and with a different experimental team. A further goal was to investigate high dilution effects on variability. MATERIAL AND METHODS: A structured experiment was performed blind over 9 weeks, using wheat seeds previously stressed with a sublethal dose of As(2)O(3). The seeds were then treated with either potentized As(2)O(3) (5x, 15x, 25x, 35x, 45x), potentized water (equivalent potencies) or diluted As(2)O(3) (10(-5), 10(-15), 10(-25), 10(-35), 10(-45)). The working variable was the stem length, measured after 4, 5, 6 and 7 days. RESULTS: Some potencies (As(2)O(3) 45x and H(2)O 45x) induced a relevant increase in seedling growth and/or a variability decrease. Diluted As(2)O(3) did not induce any significant results. CONCLUSIONS: Confirmation of a significant stimulating effect on seedling growth and a significant decrease of variability was obtained with ultra-high dilutions at the 45x potency. The model of wheat germination and growth has been confirmed to be a good tool for basic research in homeopathy.
Maurizio Brizzi; Lisa Lazzarato; Daniele Nani; Francesco Borghini; Maurizio Peruzzi; Lucietta Betti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-10-13
Journal Detail:
Title:  Forschende Komplementärmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine     Volume:  12     ISSN:  1424-7364     ISO Abbreviation:  Forsch Komplementarmed Klass Naturheilkd     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-18     Completed Date:  2006-02-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100958201     Medline TA:  Forsch Komplementarmed Klass Naturheilkd     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  IM    
Department of Statistical Sciences, Bologna University, Italy.
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MeSH Terms
Arsenicals / pharmacology*
Germination / drug effects
Growth Inhibitors / pharmacology*
Models, Biological*
Oxides / pharmacology*
Reproducibility of Results
Statistics as Topic
Triticum / drug effects*,  growth & development
Reg. No./Substance:
0/Arsenicals; 0/Growth Inhibitors; 0/Oxides; 1327-53-3/arsenic trioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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