| The biomechanics of locomotor compensation after peripheral nerve lesion in the rat. | |
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MedLine Citation:
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PMID: 22309981 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Functional recovery in animal models of nervous system disorders commonly involves behavioural compensation, in which animals alter the use of their limbs after injury, making it difficult to distinguish 'true' recovery from substitution of novel movements. The purpose of this study is to investigate how abnormal movements are produced by using biomechanical assessment of limb joint motion, an approach commonly used to diagnose human pathological gait. Rats were trained to cross a runway whilst kinetic (ground reaction forces) and kinematic (limb segment positions) data were synchronously recorded. Inverse dynamic analysis was used to calculate limb joint moments, or torques, and joint mechanical power throughout the stride for major joints of the forelimbs and hindlimbs, both before and after denervation of a major ankle extensor muscle. Before surgery, rats moved with joint moment and power profiles comparable to other quadrupeds, with differences attributable to species variation in limb posture. After surgery, rats trotted asymmetrically, with a near plantigrade stance of the left hindlimb. Surprisingly, ankle joint moments and power were largely preserved, with dramatic reductions in range of motion and joint moments at the proximal joints of the affected limb. Stiffening of the proximal limb compensated for increased compliance at the ankle but decreased the total mechanical work done by the injured limb. In turn, more work was done by the opposite, i.e. uninjured, hindlimb. This is the first study to quantify the biomechanical adjustments made within and between limbs in laboratory rodents after nervous system injury. |
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Authors:
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Sean W Bennett; Joel L Lanovaz; Gillian D Muir |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-30 |
Journal Detail:
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Title: Behavioural brain research Volume: - ISSN: 1872-7549 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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