Document Detail


A biomarker for severity of Alzheimer's disease: (1)H-NMR resonances in cerebrospinal fluid correlate with performance in mini-mental-state-exam.
MedLine Citation:
PMID:  22288505     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Context: There is no valid biomarker for severity of Alzheimer's disease (AD) available until now. Objective: Therefore, we investigated (1)H-NMR spectroscopy for specific resonances as biomarkers for severity of AD. Materials and methods: Cerebrospinal fluid (CSF) of patients with diagnosed AD and healthy control subjects was analysed by one-dimensional water-suppressed (1)H-NMR spectroscopy. The resonances were correlated with the cognitive performance of the patients and controls. Results: Specific (1)H-NMR resonances showed higher intensities in AD patients than in control subjects. Mini-mental-state-exam scores correlated with (1)H-NMR resonances in AD patients. Discussion and conclusion: (1)H-NMR resonances of CSF are obviously valid biomarker for severity of AD, despite the lack of knowledge of the underlying molecular structure. Successful isolation and identification of these substances will most likely provide details to the pathophysiology of AD.
Authors:
Felix Kork; André Gentsch; Jan Holthues; Rainer Hellweg; Vera Jankowski; Martin Tepel; Walter Zidek; Joachim Jankowski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  17     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  36-42     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology and Intensive Care Medicine, Charité-Universitäetsmedizin Berlin , Campus Virchow-Klinikum and Campus Charité Mitte, Berlin , Germany.
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