Document Detail

A biomarker for severity of Alzheimer's disease: (1)H-NMR resonances in cerebrospinal fluid correlate with performance in mini-mental-state-exam.
MedLine Citation:
PMID:  22288505     Owner:  NLM     Status:  In-Data-Review    
Context: There is no valid biomarker for severity of Alzheimer's disease (AD) available until now. Objective: Therefore, we investigated (1)H-NMR spectroscopy for specific resonances as biomarkers for severity of AD. Materials and methods: Cerebrospinal fluid (CSF) of patients with diagnosed AD and healthy control subjects was analysed by one-dimensional water-suppressed (1)H-NMR spectroscopy. The resonances were correlated with the cognitive performance of the patients and controls. Results: Specific (1)H-NMR resonances showed higher intensities in AD patients than in control subjects. Mini-mental-state-exam scores correlated with (1)H-NMR resonances in AD patients. Discussion and conclusion: (1)H-NMR resonances of CSF are obviously valid biomarker for severity of AD, despite the lack of knowledge of the underlying molecular structure. Successful isolation and identification of these substances will most likely provide details to the pathophysiology of AD.
Felix Kork; André Gentsch; Jan Holthues; Rainer Hellweg; Vera Jankowski; Martin Tepel; Walter Zidek; Joachim Jankowski
Related Documents :
21739385 - Isolated dizziness/vertigo, vascular risk factors and stroke.
22021635 - Systematic review of sonographic chronic cerebrospinal venous insufficiency findings in...
19948535 - Comprehensive genotype-phenotype analysis in 230 patients with tetralogy of fallot.
20819625 - Diagnosis and fine localization of deletion region in wolf-hirschhorn syndrome patients.
16224035 - Central venous access in the home parenteral nutrition population-you picc.
14611115 - Increased serum levels of interleukin-15 in rheumatoid arthritis with long- term disease.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  17     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  36-42     Citation Subset:  IM    
Department of Anesthesiology and Intensive Care Medicine, Charité-Universitäetsmedizin Berlin , Campus Virchow-Klinikum and Campus Charité Mitte, Berlin , Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Exercise as a model to study redox homeostasis in blood: the effect of protocol and sampling point.
Next Document:  Somatic neuropathy is an independent predictor of all- and diabetes-related mortality in type 2 diab...