| The biomarker plasma galectin-3 in advanced heart failure and survival with mechanical circulatory support devices. | |
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MedLine Citation:
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PMID: 23352394 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: During screening of heart transplantation (HTx) candidates supported by ventricular assist devices (VADs) for plasma biomarkers we found that galectin-3 (Gal-3) was increased pre-operatively in patients who later died during VAD support. Therefore, we analyzed the predictive value of plasma Gal-3 in the context of other potential clinical risk factors for death on device (DOD) in a cohort of 175 VAD patients. METHODS: We analyzed numerous clinical factors and plasma Gal-3 levels of 175 VAD patients before device implantation. Eighty VAD patients were successfully bridged to HTx (BTT, 45.7%), 80 (45.7%) died on VAD, 2 recovered on device (BTR, 1.1%) and 13 (7.4%) were still on device. Uni- and multivariate analyses were performed to assess the importance of Gal-3 with respect to other clinical factors. Myocardial gene expression of Gal-3 was investigated in apex samples by RT-PCR (n = 30) and Western blotting (n = 45). RESULTS: Plasma Gal-3 levels were higher in VAD patients than in controls (16.6±9.3 vs 9.5±3.9 ng/ml, p < 0.0001). Cox regression showed several clinical factors and type of VAD as independent outcome predictors, but Gal-3 was not among them. Using the regression equation we grouped patients according to their factor constellation for prediction of survival on VAD. We propose a calculation method for VAD survival prediction. Gal-3 mRNA and protein were detectable in failing myocardium, but did not correlate with its plasma concentration. CONCLUSIONS: Galectin-3 levels are associated with severe heart failure but do not provide sufficient discrimination for prediction of outcomes after VAD implantation. Importantly, we were unable to confirm myocardial tissue as a primary source for the observed plasma elevations of Gal-3. |
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Authors:
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Gülsüm Erkilet; Cenk Ozpeker; Dietmar Böthig; Frank Kramer; Daniela Röfe; Birte Bohms; Michiel Morshuis; Jan Gummert; Hendrik Milting |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Volume: 32 ISSN: 1557-3117 ISO Abbreviation: J. Heart Lung Transplant. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102703 Medline TA: J Heart Lung Transplant Country: United States |
Other Details:
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Languages: eng Pagination: 221-30 Citation Subset: IM |
Copyright Information:
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Copyright © 2013 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Heart and Diabetes Center NRW, Clinic of Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann-Institute for Cardiovascular Research and Development, Bad Oeynhausen. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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