| The biology of myeloid-derived suppressor cells: the blessing and the curse of morphological and functional heterogeneity. | |
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MedLine Citation:
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PMID: 21061430 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myeloid-derived suppressor cells (MDSC) play an important role in the cellular network regulating immune responses in cancer, chronic infectious diseases, autoimmunity, and in other pathological conditions. Morphological, phenotypic and functional heterogeneity is a hallmark of MDSC. This heterogeneity demonstrates the plasticity of this immune suppressive myeloid compartment, and shows how various tumors and infectious agents can have similar biological effects on myeloid cells despite the differences in the factors that they produce to influence the immune system; however, such a heterogeneity creates ambiguity in the definition of MDSC as well as confusion regarding the origin and fate of these cells. In this review, we will discuss recent findings that help to better clarify these issues and to determine the place of MDSC within the myeloid cell lineage. |
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Authors:
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Je-In Youn; Dmitry I Gabrilovich |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: European journal of immunology Volume: 40 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-09 Completed Date: 2010-12-17 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 2969-75 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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H. Lee Moffitt Cancer Center, Tampa, FL, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Infection / immunology, pathology Myeloid Cells / cytology*, immunology* Neoplasms / immunology, pathology |
| Grant Support | |
ID/Acronym/Agency:
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CA100062/CA/NCI NIH HHS; CA84488/CA/NCI NIH HHS; R01 CA084488-14/CA/NCI NIH HHS; R01 CA100062-08/CA/NCI NIH HHS; R01 CA100062-09/CA/NCI NIH HHS; R01 CA141438-03/CA/NCI NIH HHS |
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