Document Detail


The biology of interleukin-1: emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics.
MedLine Citation:
PMID:  21744066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interleukin (IL)-1 is a proinflammatory cytokine with important roles in innate immunity, as well as in normal tissue homeostasis. Interestingly, recent studies have also shown IL-1 to function in the dynamics of the actin cytoskeleton and cell junctions. For example, treatment of different epithelia with IL-1α often results in the restructuring of the actin network and cell junctions, thereby leading to junction disassembly. In this review, we highlight new and interesting findings that show IL-1 to be a critical player of restructuring events in the seminiferous epithelium of the testis during spermatogenesis.
Authors:
Pearl P Y Lie; C Yan Cheng; Dolores D Mruk
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-07-09
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  69     ISSN:  1420-9071     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-25     Completed Date:  2012-03-12     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  487-500     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Actin Cytoskeleton / metabolism*
Humans
Intercellular Junctions / metabolism*
Interleukin-1 / metabolism*,  physiology
NF-kappa B / metabolism
Signal Transduction
Spermatogenesis
rho GTP-Binding Proteins / metabolism
Grant Support
ID/Acronym/Agency:
R01 HD056034/HD/NICHD NIH HHS; R01HD056034-02S1/HD/NICHD NIH HHS; R03 HD061401/HD/NICHD NIH HHS; R03 HD061401/HD/NICHD NIH HHS; R03 HD061401-02/HD/NICHD NIH HHS; U54 HD029990/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Interleukin-1; 0/NF-kappa B; EC 3.6.5.2/rho GTP-Binding Proteins
Comments/Corrections

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