| The biology of facial fillers. | |
| | |
MedLine Citation:
|
PMID: 19415574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The biologic behavior of a facial filler determines its advantages and disadvantages. The purpose of this article is to look at the relevant biology as part of a logical basis for making treatment decisions. Historical perspectives and biologic characteristics such as local tissue reaction (including phagocytosis and granulomatous inflammation) cross-linking, particle concentration, immunogenicity, biofilm formation, gel hardness, and collagen neogenesis are considered. Bovine collagen is the most immunogenic facial filler. Porcine and bioengineered human collagen implants have very low immunogenicity, but allergic reactions and elevations of IgG are possible. Cross-linking and concentration affect the longevity of collagen and hyaluronic acid fillers. Gel hardness affects how a hyaluronic acid filler flows through the syringe and needle. Calcium hydroxylapatite, poly-L-lactic acid, and polymethylmethacrylate fillers have been shown to stimulate collagen neogenesis. It appears that any facial filler can form a granuloma. Bacterial biofilms may play a role in the activation of quiescent granulomas. Various authors interpret the definition and significance of a granuloma differently. |
| | |
Authors:
|
Stuart H Bentkover |
Related Documents
:
|
8113624 - Enzymic determination of acidic glycoconjugates in human pancreatic juice. 9839704 - Immunochemical detection of the proteoglycans decorin and biglycan in human gingival cr... 1260004 - The interaction of collagen with alpha1-acid glycoprotein. 17564774 - Minodronic acid influences receptor activator of nuclear factor kappab ligand expressio... 19690334 - Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in ma... 8865074 - Non-ionic diffusion and carrier-mediated transport drive extracellullar ph regulation o... |
Publication Detail:
|
Type: Journal Article Date: 2009-05-04 |
Journal Detail:
|
Title: Facial plastic surgery : FPS Volume: 25 ISSN: 1098-8793 ISO Abbreviation: Facial Plast Surg Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-05-05 Completed Date: 2009-07-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8405303 Medline TA: Facial Plast Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 73-85 Citation Subset: D |
Affiliation:
|
Bentkover Facial Plastic Surgery and Laser Center, Worcester, Massachusetts 01608, USA. stuart.bentkover@drbentkover.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biocompatible Materials / administration & dosage, adverse effects, metabolism* Biofilms Cattle Chondrogenesis Collagen / administration & dosage, immunology, metabolism Cosmetic Techniques* Durapatite / administration & dosage, immunology, metabolism Face Granuloma, Foreign-Body / etiology Humans Hyaluronic Acid / administration & dosage, immunology, metabolism Injections, Subcutaneous Lactic Acid / administration & dosage, immunology, metabolism Microspheres Phagocytosis Polymers / administration & dosage, metabolism Polymethyl Methacrylate / administration & dosage, metabolism Silicones / administration & dosage, metabolism Swine |
| Chemical | |
Reg. No./Substance:
|
0/Biocompatible Materials; 0/Polymers; 0/Silicones; 0/glutaraldehyde-cross-linked collagen; 1306-06-5/Durapatite; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid; 9004-61-9/Hyaluronic Acid; 9007-34-5/Collagen; 9011-14-7/Polymethyl Methacrylate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The history of injectable facial fillers.
Next Document: Hyaluronic Acid fillers: a comprehensive review.