Document Detail


The biology of the extracellular matrix: novel insights.
MedLine Citation:
PMID:  23143224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Extracellular matrix (ECM) has both structural and regulatory roles. This update reviews the representative recent developments in diverse aspects of ECM biology relevant to inflammation, tissue destruction, fibrosis, and regeneration.
RECENT FINDINGS: Biological regulation by ECM is emerging as a major research area, driven by several new directions. Sensing of mechanical cues provided by ECM was found to be crucial in regulating cell differentiation. Transforming growth factor-β (TGF-β) is a pivotal agent in fibrosis and inflammation. A combination of structural biology and cell biology provided novel insights on the mechanisms of its activation by cellular traction and ECM. Improved understanding of how fibrillin microfibrils and associated proteins regulated TGF-β sequestration and activation was achieved by analysis of inherited connective tissue disorders having TGF-β dysregulation as an underlying pathologic mechanism. Insights on microRNA-mediated ECM regulation suggest a key role for miR-29, for which potential therapeutic roles are emerging. Advances in understanding the ECM turnover by proteinases provided novel insights on cell regulation and identified useful disease biomarkers.
SUMMARY: As a crucial modulator of cell behavior, ECM has exceptionally strong relevance and translational implications for human disease, opening novel opportunities for mechanistic understanding of disease pathogenesis as well as treatment.
Authors:
Dirk Hubmacher; Suneel S Apte
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  25     ISSN:  1531-6963     ISO Abbreviation:  Curr Opin Rheumatol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-29     Completed Date:  2013-05-17     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / blood
Extracellular Matrix / physiology*
Humans
Inflammation / physiopathology
Mechanotransduction, Cellular / physiology
MicroRNAs / physiology
Neoplasm Metastasis
Transforming Growth Factor beta / physiology
Grant Support
ID/Acronym/Agency:
AR53890/AR/NIAMS NIH HHS; EY021151/EY/NEI NIH HHS; HL107147/HL/NHLBI NIH HHS; P01 HL107147/HL/NHLBI NIH HHS; R01 AR053890/AR/NIAMS NIH HHS; R01 EY021151/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/MicroRNAs; 0/Transforming Growth Factor beta
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