| The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. | |
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MedLine Citation:
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PMID: 18177721 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all macromolecular components during each passage through the cell cycle. It is therefore not surprising that metabolic activities in proliferating cells are fundamentally different from those in nonproliferating cells. This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types. We also consider regulation of these fluxes by cellular mediators of signal transduction and gene expression, including the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR system, hypoxia-inducible factor 1 (HIF-1), and Myc, during physiologic cell proliferation and tumorigenesis. |
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Authors:
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Ralph J DeBerardinis; Julian J Lum; Georgia Hatzivassiliou; Craig B Thompson |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cell metabolism Volume: 7 ISSN: 1550-4131 ISO Abbreviation: Cell Metab. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-07 Completed Date: 2008-05-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233170 Medline TA: Cell Metab Country: United States |
Other Details:
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Languages: eng Pagination: 11-20 Citation Subset: IM |
Affiliation:
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Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104-6160, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Phosphatidylinositol 3-Kinase
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metabolism Animals Cell Proliferation* Humans Hypoxia-Inducible Factor 1 / metabolism Models, Biological Neoplasms / metabolism*, pathology* Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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K08 DK072565/DK/NIDDK NIH HHS; P01 CA104838/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypoxia-Inducible Factor 1; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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