| The biology of alkylating-agent cellular injury. | |
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MedLine Citation:
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PMID: 8468267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alkylating agents, such as nitrogen mustard, cyclophosphamide, and the nitrosoureas, have been used to treat many malignancies for more than 30 years. It is now clear that they are not only cytotoxic but also mutagenic and carcinogenic. The initial alkylation event, monoadduct formation on ring nitrogens or extra-cyclic oxygens of nucleotide bases, can result in chromosomal loss or single base mutation, both of which can lead to malignant transformation. The bone marrow is particularly sensitive to these events, and acute myelogenous leukemia is the most common malignancy caused by alkylating agents. Mechanisms of genetic damage and mutagenesis are discussed. |
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Authors:
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L N Shulman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Hematology/oncology clinics of North America Volume: 7 ISSN: 0889-8588 ISO Abbreviation: Hematol. Oncol. Clin. North Am. Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-05-10 Completed Date: 1993-05-10 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8709473 Medline TA: Hematol Oncol Clin North Am Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 325-35 Citation Subset: IM |
Affiliation:
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Division of Hematology-Oncology, Brigham and Women's Hospital, Boston, Massachusetts. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkylating Agents
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chemistry,
pharmacology* Animals Antineoplastic Agents / chemistry, pharmacology* DNA / chemistry, drug effects* Humans Mutagens / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Alkylating Agents; 0/Antineoplastic Agents; 0/Mutagens; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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