Document Detail

The biological clock of very premature primate infants is responsive to light.
MedLine Citation:
PMID:  10051658     Owner:  NLM     Status:  MEDLINE    
Each year more than 250,000 infants in the United States are exposed to artificial lighting in hospital nurseries with little consideration given to environmental lighting cycles. Essential in determining whether environmental lighting cycles need to be considered in hospital nurseries is identifying when the infant's endogenous circadian clock becomes responsive to light. Using a non-human primate model of the developing human, we examined when the circadian clock, located in the hypothalamic suprachiasmatic nuclei (SCN), becomes responsive to light. Preterm infant baboons of different ages were exposed to light (5,000 lux) at night, and then changes in SCN metabolic activity and gene expression were assessed. After exposure to bright light at night, robust increases in SCN metabolic activity and gene expression were seen at ages that were equivalent to human infants at 24 weeks after conception. These data provide direct evidence that the biological clock of very premature primate infants is responsive to light.
H Hao; S A Rivkees
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  96     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-15     Completed Date:  1999-04-15     Revised Date:  2013-04-17    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2426-9     Citation Subset:  IM    
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA.
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MeSH Terms
Biological Clocks / physiology*
Carbon Radioisotopes / pharmacokinetics
Circadian Rhythm
Deoxyglucose / pharmacokinetics
Gene Expression Regulation / radiation effects*
Infant, Newborn
Infant, Premature / physiology*
RNA, Messenger / genetics
Suprachiasmatic Nucleus / metabolism,  radiation effects*
Transcription, Genetic / drug effects
Grant Support
Reg. No./Substance:
0/Carbon Radioisotopes; 0/RNA, Messenger; 154-17-6/Deoxyglucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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