Document Detail

The biologic response to titanium phosphate. A new synthetic mineral fiber.
MedLine Citation:
PMID:  578688     Owner:  NLM     Status:  MEDLINE    
Titanium phosphate, a new manmade fiber, was evaluated by intratracheal and intraperitoneal techniques in rats and hamsters to assess the fibrogenic potential and possible hazard to man. Titanium phosphate fibers structurally resemble asbestos insofar as they are composed of bundles of submicronic fibers. A slight, dose-related fibrogenic response to the fiber was observed subsequent to the intratracheal injection of a 50- and 10-mg/kg but not 2-mg/kg dose in rats or any of these three doses in the hamster. Intraperitoneal administration of 10 or 2 mg/kg of the fibers in rats or hamsters induced no abdominal tumors considered related to treatment. In contrast, approximately 34% of rats given an intraperitoneal injection of 2 mg/kg of asbestos developed abdominal tumors; no tumors developed in hamsters injected with asbestos.
P Gross; R J Kociba; G L Sparschu; J M Norris
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  101     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1977-11-25     Completed Date:  1977-11-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  550-4     Citation Subset:  AIM; IM    
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MeSH Terms
Abdominal Neoplasms / etiology*
Asbestos / adverse effects
Bronchi / drug effects
Dose-Response Relationship, Drug
Lung / cytology,  drug effects*
Lymph Nodes / drug effects
Time Factors
Titanium / adverse effects*
Reg. No./Substance:
1332-21-4/Asbestos; 7440-32-6/Titanium; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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