Document Detail

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling.
MedLine Citation:
PMID:  25306244     Owner:  NLM     Status:  Publisher    
Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We apply a bioinspired, omniphobic coating to tubing and catheters and show that it completely repels blood and suppresses biofilm formation. The coating is a covalently tethered, flexible molecular layer of perfluorocarbon, which holds a thin liquid film of medical-grade perfluorocarbon on the surface. This coating prevents fibrin attachment, reduces platelet adhesion and activation, suppresses biofilm formation and is stable under blood flow in vitro. Surface-coated medical-grade tubing and catheters, assembled into arteriovenous shunts and implanted in pigs, remain patent for at least 8 h without anticoagulation. This surface-coating technology could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.
Daniel C Leslie; Anna Waterhouse; Julia B Berthet; Thomas M Valentin; Alexander L Watters; Abhishek Jain; Philseok Kim; Benjamin D Hatton; Arthur Nedder; Kathryn Donovan; Elana H Super; Caitlin Howell; Christopher P Johnson; Thy L Vu; Dana E Bolgen; Sami Rifai; Anne R Hansen; Michael Aizenberg; Michael Super; Joanna Aizenberg; Donald E Ingber
Related Documents :
21977574 - Medical education in saudi arabia: a review of recent developments and future challenges.
24744274 - Patient-accessible tool for shared decision making in cardiovascular primary prevention...
22944654 - N-acetylcysteine as a potentially useful medication to prevent conversion to schizophre...
21967384 - Similar secondary stroke prevention and medication persistence rates among rural and ur...
12050904 - From apes to humans: locomotion as a key feature for phylogeny.
8357674 - Deafness and dentistry.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-12
Journal Detail:
Title:  Nature biotechnology     Volume:  -     ISSN:  1546-1696     ISO Abbreviation:  Nat. Biotechnol.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-12     Completed Date:  -     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  9604648     Medline TA:  Nat Biotechnol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Automated estimation of disease recurrence in head and neck cancer using routine healthcare data.
Next Document:  Comparative analyses of C4 and C3 photosynthesis in developing leaves of maize and rice.