Document Detail


A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling.
MedLine Citation:
PMID:  25306244     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We apply a bioinspired, omniphobic coating to tubing and catheters and show that it completely repels blood and suppresses biofilm formation. The coating is a covalently tethered, flexible molecular layer of perfluorocarbon, which holds a thin liquid film of medical-grade perfluorocarbon on the surface. This coating prevents fibrin attachment, reduces platelet adhesion and activation, suppresses biofilm formation and is stable under blood flow in vitro. Surface-coated medical-grade tubing and catheters, assembled into arteriovenous shunts and implanted in pigs, remain patent for at least 8 h without anticoagulation. This surface-coating technology could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.
Authors:
Daniel C Leslie; Anna Waterhouse; Julia B Berthet; Thomas M Valentin; Alexander L Watters; Abhishek Jain; Philseok Kim; Benjamin D Hatton; Arthur Nedder; Kathryn Donovan; Elana H Super; Caitlin Howell; Christopher P Johnson; Thy L Vu; Dana E Bolgen; Sami Rifai; Anne R Hansen; Michael Aizenberg; Michael Super; Joanna Aizenberg; Donald E Ingber
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-12
Journal Detail:
Title:  Nature biotechnology     Volume:  -     ISSN:  1546-1696     ISO Abbreviation:  Nat. Biotechnol.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-12     Completed Date:  -     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  9604648     Medline TA:  Nat Biotechnol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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