Document Detail


In vivo biocompatibility of a plasma-activated, coronary stent coating.
MedLine Citation:
PMID:  22889486     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Bare metal and drug-eluting coronary stents suffer an inherent lack of vascular cell and blood compatibility resulting in adverse patient responses. We have developed a plasma-activated coating (PAC) for metallic coronary stents that is durable, withstands crimping and expansion, has low thrombogenicity and can covalently bind proteins, linker-free. This has been shown to enhance endothelial cell interactions in vitro and has the potential to promote biointegration of stents. Using the rabbit denuded iliac artery model, we show for the first time that PAC is a feasible coating for coronary stents in vivo. The coating integrity of PAC was maintained following implantation and expansion. The rate of endothelialization, strut coverage, neointimal response and the initial immune response were equivalent to bare metal stents. Furthermore, the initial thrombogenicity caused by the PAC stents showed a reduced trend compared to bare metal stents. This work demonstrates a robust, durable, non-cytotoxic plasma-based coating technology that has the ability to covalently immobilize bioactive molecules for surface modification of coronary stents. Improvements in the clinical performance of implantable cardiovascular devices could be achieved by the immobilization of proteins or peptides that trigger desirable cellular responses.
Authors:
Anna Waterhouse; Steven G Wise; Yongbai Yin; Buchu Wu; Barbara James; Hala Zreiqat; David R McKenzie; Shisan Bao; Anthony S Weiss; Martin K C Ng; Marcela M M Bilek
Related Documents :
3776676 - Anatomic variants of the hepatic arteries.
12169986 - Common bile duct compression by an abdominal aortic aneurysm: an unusual cause of bilia...
12874516 - Evaluation of optimal timing of arterial phase imaging for the detection of hypervascul...
2305086 - Spontaneous hepatic hemorrhage in preeclampsia: treatment with hepatic arterial emboliz...
7212826 - Ebstein's anomaly: surgical treatment with tricuspid replacement without right ventricu...
19388106 - Halting the effects of flow enhancement with effective intermittent zeugmatographic enc...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-10
Journal Detail:
Title:  Biomaterials     Volume:  -     ISSN:  1878-5905     ISO Abbreviation:  Biomaterials     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
School of Molecular Bioscience, University of Sydney, NSW 2006, Australia; Heart Research Institute, Sydney, NSW 2042, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A systematic review of animal models used to study nerve regeneration in tissue-engineered scaffolds...
Next Document:  Light activated cell migration in synthetic extracellular matrices.