| A biochemical oscillator explains several aspects of Myxococcus xanthus behavior during development. | |
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MedLine Citation:
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PMID: 15496464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During development, Myxococcus xanthus cells produce a series of spatial patterns by coordinating their motion through a contact-dependent signal, the C-signal. C-signaling modulates the frequency at which cells reverse their gliding direction. It does this by interacting with the Frz system (a homolog of the Escherichia coli chemosensory system) via a cascade of covalent modifications. Here we show that introducing a negative feedback into this cascade results in oscillatory behavior of the signaling circuit. The model explains several aspects of M. xanthus behavior during development, including the nonrandom distribution of reversal times, and the differences in response of the reversal frequency to both moderate and high levels of C-signaling at different developmental stages. We also propose experiments to test the model. |
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Authors:
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Oleg A Igoshin; Albert Goldbeter; Dale Kaiser; George Oster |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. Date: 2004-10-20 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 101 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-03 Completed Date: 2004-12-06 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 15760-5 Citation Subset: IM |
Affiliation:
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Department of Physics, University of California, Berkeley, CA 94720, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Proteins
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physiology Biological Clocks / physiology* Chemotaxis / physiology Feedback Methyltransferases / physiology Models, Biological* Movement Myxococcus xanthus / growth & development*, physiology* Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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GM 23441/GM/NIGMS NIH HHS; GM 59875-02/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/FrzCD protein, Myxococcus xanthus; EC 2.1.1.-/Methyltransferases; EC 2.1.1.-/chemotaxis methyltransferase |
| Comments/Corrections | |
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