| A biochemical and morphological study of the altered growth pattern of central catecholamine neurons following 6-hydroxydopamine. | |
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MedLine Citation:
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PMID: 626876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study the effect of administering 6-hydroxydopamine (6-OHDA) intracisternally on brain catecholamine content and fluorescence patterns of cerebellar processes was examined. It was found that intracisternal injection of 6-OHDA resulted in widely diverging effects depending upon the dose of 6-OHDA, age of the animal upon injection and the length of the post injection interval. Small doses of 6-OHDA (3 and 10 microgram) selectively depleted telencephalic and upper brain stem NE while larger doses of 6-OHDA (30 and 100 microgram) infringed on dopaminergic as well as noradrenergic neurons. In addition, the lower doses of 6-OHDA, but not the higher ones, led to an approximately two-fold accumulation of NE in the lower brain stem and cerebellum. Morphological observations suggested that the cerebellar norepinephrine accumulation after 10 microgram 6-OHDA was attributable primarily to an invasion of noradrenergic processes into the cerebellum. |
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Authors:
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R J Konkol; E G Bendeich; G R Breese |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 140 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1978 Jan |
Date Detail:
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Created Date: 1978-04-26 Completed Date: 1978-04-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 125-35 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Animals, Newborn Brain / drug effects* Brain Stem / drug effects Catecholamines / metabolism* Cerebellum / drug effects Dopamine / metabolism Dose-Response Relationship, Drug Female Hippocampus / drug effects Hydroxydopamines / administration & dosage, pharmacology* Hypothalamus / drug effects Male Norepinephrine / metabolism Rats Telencephalon / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Hydroxydopamines; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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