Document Detail


The bioavailability of phenylbutazone in the horse.
MedLine Citation:
PMID:  3604253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
[phenyl-14C]-Phenylbutazone was administered to 2 horses p.o. and i.v. on separate occasions. Plasma levels and urinary and faecal elimination of 14C were monitored for up to 7 days after dosing. Phenylbutazone was rapidly and extensively absorbed after oral administration, and its bioavailability was 91% assessed by comparison of plasma AUCs of unchanged drug after p.o. and i.v. administration. The plasma elimination half-life of phenylbutazone was 9.7 h and this was independent of the route of administration. The pattern of elimination of phenylbutazone was independent of the route of administration, with 55% of the dose being found in the urine in 3 days and a further 39% in the faeces in 7 days. These data, which are the first reports of the absolute bioavailability and excretion pathways of phenylbutazone in the horse, are discussed in terms of their significance for the gastrointestinal toxicity of this drug.
Authors:
P B Smith; J Caldwell; R L Smith; M W Horner; M S Moss
Related Documents :
10574273 - Pharmacokinetics of florfenicol after treatment of pigs with single oral or intramuscul...
9601143 - The pharmacokinetics of moxidectin after oral and subcutaneous administration to sheep.
1715493 - Long-term studies on regression of left ventricular hypertrophy.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  17     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-31     Completed Date:  1987-07-31     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  435-43     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Biological Availability
Digestive System / drug effects
Half-Life
Horses / metabolism*
Injections, Intravenous
Kinetics
Mathematics
Phenylbutazone / administration & dosage,  metabolism*
Chemical
Reg. No./Substance:
50-33-9/Phenylbutazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of antibiotic pretreatments on the metabolism and excretion of [U14C](+)-catechin [( U14C](+...
Next Document:  Incorporation of radioactivity into amino acids and fatty acids after administration of 14C-geranylg...