Document Detail

The 'bio-assay' quality of life might be a better marker of disease activity in acromegalic patients than serum total IGF-I concentrations.
MedLine Citation:
PMID:  15745929     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the quality of life (QoL) in acromegalic patients in relation to biochemical parameters. DESIGN AND METHODS: Single-center, open label study in 14 acromegalic patients (eight woman and six men, age 33-77 years), with normal serum IGF-I levels during long-term treatment with monthly injections of 20 mg of long-acting octreotide. We investigated which biochemical parameter might reflect optimal QoL, using the SF-36 questionnaire. RESULTS: We observed that six patients had a low QoL score at baseline in the same range as observed in cancer patients. The other eight patients had a normal QoL. GH, IGF-I nor free IGF-I could discriminate these two subgroups at baseline. After skipping one monthly injection, all six subjects with the low QoL escaped in their free IGF-I concentrations. Also total IGF-I concentrations escaped in four of these six. In the subjects with normal QoL, free IGF-I levels remained normal in all, while total IGF-I levels only escaped in one. CONCLUSIONS: This study tells us that the currently used biochemical criteria for disease control in acromegaly might be sufficient in assessing long-term mortality and morbidity, but they are insufficient in addressing the most important parameter from the patient's perspective--QoL.
Ingrid E Bonapart; Ron van Domburg; Saskia M T H ten Have; Wouter W de Herder; Ruud A M Erdman; Joop A M J L Janssen; Aart Jan van der Lely
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  152     ISSN:  0804-4643     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-03-04     Completed Date:  2005-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  217-24     Citation Subset:  IM    
Department of Endocrinology, Erasmus Medical Centre, University Hospital of Rotterdam, Rotterdam, The Netherlands.
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MeSH Terms
Acromegaly / diagnosis*,  drug therapy,  psychology*
Antineoplastic Agents, Hormonal / administration & dosage,  adverse effects
Biological Markers
Human Growth Hormone / blood
Insulin-Like Growth Factor Binding Protein 3 / blood
Insulin-Like Growth Factor I / metabolism*
Middle Aged
Octreotide / administration & dosage,  adverse effects
Quality of Life*
Severity of Illness Index*
Reg. No./Substance:
0/Antineoplastic Agents, Hormonal; 0/Biological Markers; 0/Insulin-Like Growth Factor Binding Protein 3; 12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I; 83150-76-9/Octreotide

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