Document Detail


CCAAT/enhancer-binding protein alpha mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase.
MedLine Citation:
PMID:  16807249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Excessive hepatic gluconeogenesis and glucose production are important contributors to hyperglycemia in both type 1 and type 2 diabetes. In diabetic humans and animal models, elevated levels of p38 mitogen-activated protein kinase (p38) are observed in several tissues. Our study shows that activity of p38 is significantly elevated in livers of db/db or streptozocin-induced type 1 diabetic mice. Using cultured hepatoma cells, we find that activation of p38 enhances expression of hepatic gluconeogenic gene phosphoenolpyruvate carboxykinase (PEPCK). Furthermore, our studies demonstrate that activation of p38 stimulates phosphorylation of CCAAT/enhancer-binding protein alpha (C/EBPalpha) at serine 21 and increases its transactivation activity in the context of PEPCK gene transcription. Our results indicate that C/EBPalpha mediates p38-stimulated PEPCK transcription in liver cells.
Authors:
Liping Qiao; Ormond A MacDougald; Jianhua Shao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-27
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  281     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-21     Completed Date:  2006-11-06     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  24390-7     Citation Subset:  IM    
Affiliation:
Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
CCAAT-Enhancer-Binding Protein-alpha / metabolism*
Cell Line, Tumor
Diabetes Mellitus, Experimental / metabolism
Diabetes Mellitus, Type 1 / metabolism
Enzyme Activation
Humans
Liver / metabolism*
Male
Mice
Mice, Inbred C57BL
Phosphoenolpyruvate Carboxykinase (ATP) / metabolism
Phosphorylation
Promoter Regions, Genetic
Transcriptional Activation
p38 Mitogen-Activated Protein Kinases / metabolism*
Chemical
Reg. No./Substance:
0/CCAAT-Enhancer-Binding Protein-alpha; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases; EC 4.1.1.49/Phosphoenolpyruvate Carboxykinase (ATP)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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